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ea0029p809 | Endocrine tumours and neoplasia | ICEECE2012

Immunohistochemical, ChIP, and microarray analysis reveals how stromal AR controls prostate cancer outcome through fibroblast specific action of androgen signalling on ECM production and DNA licensing

Leach D. , Need E. , DeFranco D. , Pinnock C. , Chopra S. , Taylor R. , Risbridger G. , Buchanan G.

A breakdown in stromal-epithelial interactions mediated by androgens is emerging as a key factor in prostate cancer (PCa) aetiology and progression. Currently however, we have limited knowledge of the mechanics of androgen and androgen receptor (AR) action in prostate stroma, or how dysfunction in that compartment contributes to the disease process.In this study, immunohistochemical analysis of 64 PCa samples revealed an inverse relationship between stro...

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Endocrine Abstracts

Immunohistochemical, ChIP, and microarray analysis reveals how stromal AR controls prostate cancer outcome through fibroblast specific action of androgen signalling on ECM production and DNA licensing

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